Sam & Max 205: What's New Beelzebub? starts off where the previous episode ended. Sam and Max had found Bosco on a spaceship piloted by mariachis who travel through time in order to sing to people on their birthday. While they had returned Bosco's body to its rightful shape, they inadvertently sent him to hell, and now Sam and Max must travel there in order to get their local store clerk's soul back.
When our duo awaken, they find themselves in the subway under their office where Harry Moleman (longtime Sam & Max fans should remember him) is Death and won't let anyone onto the Soul Train who doesn't have a token.
When you do get to hell, you will see that it is a corporate office where every day is Monday and it is always one minute to quitting time. The cubes are populated by characters from past episodes like Hugh Bliss and Brady, but the real treat is the back room where victims of our heroes' antics get their own personal Hell. Before the end of the adventure, you will have to free Stinkey (the old one, not the girl), Bosco, Santa, his elf and the Desoto. You will also, inadvertently, be responsible for Satan's firing and subsequent re-hiring.