As far as presentation goes, Lost Cities goes about as far as it has to. The play area and cards look good and give off an appropriate, old time "Jungle Cruise"-style expedition feel, although they aren't incredibly impressive. It's easy to tell where all of the important things on the playfield are, though the artwork is incredibly blurry which makes it hard to appreciate the artwork on each card. Still, it does what it has to, which is about all you can ask from a card game.
Sound is as nondescript as the rest of the presentation. The background music is low key enough that it doesn't get in the way, yet there's only one song and it can become tiresome after a few games.