Big Mutha Truckers puts you in the driver's seat, literally, of an over-decorated, under-powered diesel truck. As one of four children of a matriarchal trucking tycoon who is near retirement, it is your task to accumulate more money than your siblings in two months so the company can be yours. Ideally, this would be as simple as transporting enough goods to make a killing, but in practice things are not so easy.
The first bad signal you get is from the shotgun-toting mother, which will give you a pretty good idea of the environment you will be spending the next 60 days in. The next omen of doom is her offspring. This rag-tag gang of four, any one of which you can control, looks as if they have been scraped off, forcefully mind you, from the bottom of the barrel.
You're lot in life, should you choose to accept it, is to make more money than your rival siblings in two months. This can be done in a number of ways. The region that Big Mutha Truckers takes place in is full of towns who buy and sell goods at dynamic prices. This method of income will be your main one, as you will get tips on which towns need what items and where these items are selling for cheap. There are also various alternative ways to supplement your financial holdings. When you are on the road between towns, other truckers will challenge you to races. The first one to the target town gets the cash, while the other one has to pay up. There are also slot machines in bars, loan sharks who would like nothing more than to give you money (for a price), and special missions you can take on (these are not easy).