Atelier Rorona Plus: The Alchemist Of Arland starts off by introducing you to your main character, Rorona, who works at the Atelier (an alchemist’s workshop) for Astrid. One day, a royal messenger shows up and tells her that the shop is to be closed down as ordered by the king. Astrid is supposed to go to the castle and see them about it, but Astrid doesn’t want to and sends Rorona instead. When she gets to the castle, the messenger (whose name is Sterk) tells her that she can save the workshop. She will be given an assignment every three months for the next three years. Provided she completes the assignments, the workshop will be safe at the end of three years. This means that you will have 12 assignments total.
They will be some kind of alchemical assignment and they are timed. You will need to go see Sterk to turn in items and complete assignments, but you can also take side quests by visiting Esty at the front desk of the castle. I highly recommend you check out these side quests. Eventually, Esty will have "friend requests" for you that will help make the townspeople like you (and the workshop) more. Even later, you will get bounty quests. Anyway, Astrid decides to just leave the entire workshop to Rorona and let her deal with it all so that she doesn’t have to. Rorona isn’t really sure she can do it, but what choice does she have? Luckily, she will have friends, even Sterk and Esty, to help her and even fight with her on the way.
You need to learn all about Synthesis. It can be used to make lots of things, but be careful because it takes time and energy and you’re on limited time. You can sleep on the couch to recover energy, but that also takes time. After the basics, you’ll get your first assignment. It’s not very hard to complete the assignments, but I recommend you get them done as soon as you can so you’re free to work on optional things without worry. Just keep on going and eventually you’ll get to the bottom of everything.